KMID : 1130320080510080834
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Korean Journal of Pediatrics 2008 Volume.51 No. 8 p.834 ~ p.841
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Detection and clinical manifestations of twelve respiratory viruses in hospitalized children with acute lower respiratory tract infections : Focus on human metapneumovirus;human rhinovirus and human coronavirus
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Kim Kum-Hyang
Park Joon-Soo Kim Yong-Bae Lee Jeong-Ho Kim Chang-Jin Jung Dong-Jun Sun Dong-Shin Choi Young-Jin
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Abstract
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Purpose:This study was perfomed to analyze in detail the viral etiology of acute lower respiratory tract infections (ALRI) in Cheunan, Korea by multiplex RT-PCR, including human rhinovirus (hRV) and newly identified viruses such as human metapneumovirus (hMPV) and human coronavirus (HCoV-OC43, HCoV-229E/NL63).
Methods:Nasopharyngeal aspirates (NPA) were collected from 863 hospitalized children with ALRI on the first day of admission at Soonchunhyang University Cheonan Hospital and analyzed by multiplex RT-PCR from December 2005 to November 2006.
Results:Viral agents were detected from 474 subjects (54.9%). The identified viral pathogens were hRV 9.2%, hMPV 6.8%, HCoV-229E/NL63 1.4%, and HCoV-OC43 2.1%. Coinfections with > or =2 viruses were observed in 108 patients (22.8%). The major period of viral ALRI was the first year of life. Clinical diagnoses of viral ALRI were pneumonia (59.5%), bronchiolitis (24.7%), tracheobronchitis (11.4%), and croup (4%). The most common causes of bronchiolitis was respiratory syncytial virus B (RSV B), whereas hMPV, hRV, HCoV-229E/NL63, and HCoV-OC43 were commonly found in patients with pneumonia. The number of hMPV infections peaked between March and May 2006. HCoV-OC43 was prevalent from November to February 2006, whereas HCoV-229E and hRV were detected throughout the year.
Conclusion:Although the study was confined to one year, hMPV was not detected during winter and peaked between March and April, which was not consistent with previous studies¡¯. This present study indicates that HCoV is a less common respiratory pathogen in cases of ALRI in Korean children.
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KEYWORD
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Respiratory virus, Repiratory infectionsm, RT-PCR, Children
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